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KMID : 0903520080510010044
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
2008 Volume.51 No. 1 p.44 ~ p.48
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Anti-inflammatory Effect Of Extracts from Cheongmoknosang (Morus alba L.) in Lipopolysaccharide-stimulated Raw Cells
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Cho Young-Je
An Bong-Jeun
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Abstract
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With extracts from Cheongmoknosang, anti-inflammatory effect was examined in LPS-stimulated Raw 264.7 cells. LPS (10 ng/ml) treatment increased the production of inflammatory cytokines, IL-1β, IL-6 and TNF-α but the ethanol extracts from Cheongmoknosang slightly decreased the production of TNF-α and also reduced the expression of iNOS and the production of COX-2. It seems that anti-inflammatory effects of ethanol extracts from Cheongmoknosang is partly due to the inhibition of iNOS and COX-2 expression by inhibiting nuclear translocation of NF-κB and AP-1 in Raw 264.7 cells.
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KEYWORD
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anti-inflammatory, Cheongmoknosang leaves, effectextracts
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